Online Program & Event Guide

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9:00am- 3:00pm Educational Sessions (2nd Floor Classrooms and Bray Room)

12:30pm Pick up lunch bags (2nd Floor Lounge)

2:15pm - 3:00pm Break for coffee & refreshments

3:00pm - 6:00pm Colloquium: Cell Painting in Drug Discovery

SBI2 is leading a Cell Painting for Drug Discovery Colloquium, an exciting opportunity for the SBI2 community to participate in an interactive discussion. This colloquium will address the state of the art in Cell Painting, including adaptations of imaging and analysis for drug discovery, challenges and opportunities, and the future of this approach. This session will be conducted by thought leaders in the field from the Broad Institute and the pharmaceutical industry.

3:00 - 3:15 Welcome & Introduction Justin Boyd, (Pfizer)
3:15 - 4:00 State of the art in Cell Painting Santosh Hariharan, (Pfizer)
4:00 - 4:45 The Future of Cell Painting Anne Carpenter, (Broad Institute)
4:45 - 5:30 Panel Discussion on Cell Painting in Drug Discovery Justin Boyd, (Pfizer)
Santosh Hariharan, (Pfizer)
Anne Carpenter, (Broad Institute)
Veronica Soloveva, (Merck)
Susanne Swalley, (Biogen)
Mark Bray, (Novartis)
John Concannon, (Novartis)
James Evans, (PhenoVista)
Ann Hoffman, (GSK)
Patrick Faloon, (Biogen)
6:00 - 7:00

SBI2 sponsored Opening Reception (Exhibit Hall)

SBI2 Conference Scientific Program

8:00am - 5:00pm Registration Open
8:00am - 6:30pm Poster Viewing

8:50 - 9:00 Introduction & Welcome to the 6th Annual SBI2 Conference.
Myles Fennell, President SBI2
9:10 - 10:00 Opening Keynote Presentation.
Integrating Cellular and Spatial Maps for a Human Cell Atlas
Aviv Regev
Institute Member, Chair of the Faculty, Co-director of the Cell Circuits Program,
Broad Institute

Session I:         HCS-HTS successes and learnings (10:10am - 12:30pm)

Session Chairs & Scientific Program Committee:

Debra Nickischer, co-chair Regis Doyonnas, co-chair
(Yale University)       (Pfizer)

High content screening allows us to interrogate simultaneously many cellular parameters representative of the biological activity present in physiologically and disease relevant cell-based assays.   By exploring high dimensional phenotypic signatures, complex biological pathways can be mapped so that novel drugs with subtle effects or complex mechanism of actions may finally be identified. The HCS-HTS success and learning session at the 6th Annual SBI2 conference will cover success stories and lessons learned when applying these complex assays to drug discovery in industry and academia.

10:00 - 10:30 Identification of novel factors involved in the nuclear export of mRNA using RNAi and CRISPR-based cellular phenotyping screens.
Invited Speaker, Kaylene Simpson, (Head, Victorian Centre for Functional Genomics ACRF Translational Proteomics)
10:30 - 11:00  Break for coffee & exhibit viewing
11:00 - 11:30 Development and Use of a High Content Imaging-Based Phenotypic Profiling Assay for Bioactivity Screening of Environmental Chemicals.
Invited Speaker , Joshua Harrill, (National Center for Computational Toxicology, US EPA)
11:30 - 12:00 Live imaging of epigenetic landscape.
Invited Speaker, Alexey Terskikh, (Neuroscience and Aging Research Center, Sanford Burnham Institute)
12:00 - 12:20 Phenotypic Discovery Platform for Efficacious Antioxidants.
Selected abstract, Kyle Vick, (Aerie Pharmaceuticals)
12:20 - 12:30 A “Brighter” future: Introduction to unique imaging reagents from
Funakoshi Company.
10 Min Spotlight, Kelvin Lee (Funakoshi)
12:45 –1:30

Perkin Elmer Technology Spotlight Lunch

(Pechet Room, overflow rooms 214, 216, 217)

Object-Based Imaging Reduces Data Volume and Time to Results
Speaker, Alexander Schreiner, (Perkin Elmer)
An Automated Deep-learning Workflow for Analyzing HCS screens
Speaker, Oren Kraus, (PhenomicAI)

12:45 - 1:30 Poster and exhibit viewing. (Level 2)
1:50 - 2:00 Genedata Imagence® - Deep Learning Automates the Analysis of Cell Painting Assays
10 Min Spotlight, Matthias Fassler (Genedata)

Session II: Focus on Imaging in Neurological Disease and Oncology (1:50pm - 5:00pm)

Session Chairs & Scientific Program Committee:

Le Ai Trinh, co-chair Vance Lemmon, co-chair
(University of Southern California)           (University of Miami)

Phenotypic screening is increasingly dependent on modeling, computational approaches and 3D imaging to attack complex biological problems at both high-content and high-throughput. This has been especially empowering in oncology and neuroscience where the use of pluripotent stem cells, self-organized organoids and whole animal models are enabling screens for a range of cellular phenotypes from the electrophysiological profile of individual neurons to their degeneration. This session will highlight recent developments that expand our ability to understand the local environment in tumor progression and degeneration and regeneration of the nervous system.

2:00 - 2:30 High content analysis of tumor-fibroblast crosstalk in colorectal cancer
Invited Speaker, Shannon Mumenthaler, (University of Southern California)
2:30 - 3:00 Scalable Measurements of Intrinsic Excitability in Human iPS Cell- Derived Excitatory Neurons Using All-Optical Electrophysiology.
Invited Speaker, Graham Dempsey, (Q-State Biosciences)
3:00 - 3:10 Spheroid Painting with DRAQ9™:Simple Identification and Measurement in 3D Cell Culture
10 Minute Spotlight, Roy Edward, (Biostatus)
3:10 - 3:20 FAST-HDR: A novel vector system for the rapid development of knock- in cell lines
10 Minute Spotlight, Oscar Perez-Leal, (Temple University)
3:20 - 3:50 Break for coffee - exhibit & poster viewing
3:50 - 4:20 Dynamic Arrays for Profiling Antitumor Activity of CAR T Cells
Invited Speaker, Daniel Irimia, (Harvard Medical School, Massachusetts General Hospital )
4:20 - 4:40 Using a novel colorectal cancer-on-chip model to investigate tumor microenvironment-mediated cancer progression
Selected Abstract, Carly Strelez, (USC)
4:40 - 5:00 3D Co-Cultures of Prostate Cancer Patient-Derived Xenografts, Stroma, and Endothelium in a Perfused Microplate
Selected Abstract, Lindsey K Sablatura, (Rice University)
5:00 - 5:30  SBI2 Annual General Meeting (Amphitheater)
5:30 - 6:30

 SBI2 Sponsored Reception (Exhibit Hall)

SBI2 Conference Scientific Program

8:00am - 3:00pm Exhibit & Poster viewing

8:50 - 9:00  Day 2 Opening Remarks. Myles Fennell, President SBI2

Session III:            Therapeutic Drug Discovery for Complex Disease. (9:00am - 2:20pm)

Session Chairs & Scientific Program Committee:

George Lee, co-chair Daniel Levner, co-chair
(Bristol-Myers Squibb)         (Emulate)

How HCS technologies and other imaging modalities support the understanding of complex diseases
Novel technologies such as 3D models and digital pathology are transforming drug development through the quality, complexity and human-relevance of the data they produce. In particular, recent advances in Organ-Chip and organoid technologies have provided new disease models that more closely recapitulate human disease, while advances in digital pathology and image analysis allow for the appreciation of spatial relationships within the tissue microenvironment. In this session we explore these technologies and address their potential to reveal mechanisms for therapeutic response.

9:00 - 9:30 Structure-function relationships in human organ models
Invited Speaker, Janna Nawroth, (Emulate Inc)
9:30 - 10:00 Phenotyping the tumor micro-environment with advanced tissue- based multiplexing assays.
Invited Speaker, Bonnie Philipps, (Ultivue Inc)
10:00 - 10:20 Maximizing the Value of Cancer Drug Screening in Multicellular Tumor Spheroid Cultures: Are you Analyzing your 3D Tumor Models Appropriately?
Selected Abstract, Paul Johnston, (U of Pittsburg)
10:20 - 10:30 Introducing two software modules that bring new functionality in image acquisition and analysis software from Amnis, now a part of Luminex Corporation
10 Minute Spotlight, Darin Fogg, (Lunimex)
10:30 - 11:00 Break for coffee & exhibit viewing
10:30 - 12:00 Poster Presentations (authors at posters)
SBI2 High Content 2019 Poster Competition
Sponsored by ChemBridge: 1st, 2nd, & 3rd place awards
12:15 - 1:00

GE Healthcare Technology Spotlight Lunch (Pechet Room, overflow rooms 214, 216, 217)

Diving Deeper: Advances in 3D High Content Screening Solutions and Quantitative Image Analysis
Speaker, Will Marshall, (GE)

1:15 - 2:15 Closing Keynote Presentation.
From Yeast to Neurons to Patients: A Novel Drug Discovery Platform for Neurodegenerative diseases.
Chee-Yeun Chung
Scientific Co-Founder, Director, Discovery Biology
Yumanity Therapeutics

Session IV:           Machine Learning/Artificial Intelligence and/or Conventional outputs?
(2:00pm - 4:30pm)

Session Chairs & Scientific Program Committee:

Sam Cooper, co-chair Neil O. Carragher, co-chair
(Phenomic AI)          (MRC Institute of Genetics & Molecular Medicine)

Machine learning has been a feature of drug discovery for almost four decades and delivered multiple successes, with early algorithms focused around in silico optimization of compounds. So what’s all the fuss about now? In contrast to the rules and simulation based approaches of past decades, new machine learning approaches such as deep-learning allow us to extract valuable insights from a wide variety of data types, including imaging, sequencing, and compound data, without having to explicitly engineer new features for each data type. In this session we will bring together a group of researchers working on state-of-the art techniques for microscopy image analysis, and explore how imaging data can be integrated with other data modalities to answer key questions in biological and pharmaceutical research.

2:15 - 2:45 Deep learning for single cell biology
Invited Speaker, David A. Van Valen, (California Institute of Technology)
2:45- 3:15 Machine learning: a new approach enabling drug discovery
Invited Speaker, Eric Lubeck, (Insitro)
3:15 - 3:45 Break for coffee & exhibit viewing
3:45 - 4:05 Comparison of classical image analysis methods and deep-learning approaches for 3D single cell measurements within multi-cellular spheroids
Selected Abstract, Ty Voss, (NCATS/NIH)
4:05 - 4:25 Nucleus segmentation across imaging experiments: The 2018 Data Science Bowl
Selected Abstract, Juan Caicedo, (Broad Institute)
4:25 - 4:45 Awards Ceremony and Closing remarks
Myles Fennell, President SBI2