Online Program & Event Guide
9:00am- 3:00pm Educational Sessions (2nd Floor Classrooms and Bray Room)
12:30pm Pick up lunch bags (2nd Floor Lounge)
2:15pm - 3:00pm Break for coffee & refreshments
3:00pm - 6:00pm Colloquium: Cell Painting in Drug Discovery
SBI2 is leading a Cell Painting for Drug Discovery Colloquium, an exciting opportunity for the SBI2 community to participate in an interactive discussion. This colloquium will address the state of the art in Cell Painting, including adaptations of imaging and analysis for drug discovery, challenges and opportunities, and the future of this approach. This session will be conducted by thought leaders in the field from the Broad Institute and the pharmaceutical industry.
3:00 - 3:15 | Welcome & Introduction Justin Boyd, (Pfizer) |
3:15 - 4:00 | State of the art in Cell Painting Santosh Hariharan, (Pfizer) |
4:00 - 4:45 | The Future of Cell Painting Anne Carpenter, (Broad Institute) |
4:45 - 5:30 | Panel Discussion on Cell Painting in Drug Discovery Justin Boyd, (Pfizer) Santosh Hariharan, (Pfizer) Anne Carpenter, (Broad Institute) Veronica Soloveva, (Merck) Susanne Swalley, (Biogen) Mark Bray, (Novartis) John Concannon, (Novartis) James Evans, (PhenoVista) Ann Hoffman, (GSK) Patrick Faloon, (Biogen) |
6:00 - 7:00 |
SBI2 sponsored Opening Reception (Exhibit Hall) |
SBI2 Conference Scientific Program
8:00am - 5:00pm Registration Open
8:00am - 6:30pm Poster Viewing
Session I: HCS-HTS successes and learnings (10:10am - 12:30pm)
Session Chairs & Scientific Program Committee:
Debra Nickischer, co-chair | Regis Doyonnas, co-chair |
(Yale University) | (Pfizer) |
High content screening allows us to interrogate simultaneously many cellular parameters representative of the biological activity present in physiologically and disease relevant cell-based assays. By exploring high dimensional phenotypic signatures, complex biological pathways can be mapped so that novel drugs with subtle effects or complex mechanism of actions may finally be identified. The HCS-HTS success and learning session at the 6th Annual SBI2 conference will cover success stories and lessons learned when applying these complex assays to drug discovery in industry and academia.
10:00 - 10:30 | Identification of novel factors involved in the nuclear export of mRNA using RNAi and CRISPR-based cellular phenotyping screens. Invited Speaker, Kaylene Simpson, (Head, Victorian Centre for Functional Genomics ACRF Translational Proteomics) |
10:30 - 11:00 | Break for coffee & exhibit viewing |
11:00 - 11:30 | Development and Use of a High Content Imaging-Based Phenotypic Profiling Assay for Bioactivity Screening of Environmental Chemicals. Invited Speaker , Joshua Harrill, (National Center for Computational Toxicology, US EPA) |
11:30 - 12:00 | Live imaging of epigenetic landscape. Invited Speaker, Alexey Terskikh, (Neuroscience and Aging Research Center, Sanford Burnham Institute) |
12:00 - 12:20 | Phenotypic Discovery Platform for Efficacious Antioxidants. Selected abstract, Kyle Vick, (Aerie Pharmaceuticals) |
12:20 - 12:30 | A “Brighter” future: Introduction to unique imaging reagents from Funakoshi Company.10 Min Spotlight, Kelvin Lee (Funakoshi) |
12:45 –1:30 |
Perkin Elmer Technology Spotlight Lunch(Pechet Room, overflow rooms 214, 216, 217) Object-Based Imaging Reduces Data Volume and Time to Results |
12:45 - 1:30 | Poster and exhibit viewing. (Level 2) |
1:50 - 2:00 | Genedata Imagence® - Deep Learning Automates the Analysis of Cell Painting Assays 10 Min Spotlight, Matthias Fassler (Genedata) |
Session II: Focus on Imaging in Neurological Disease and Oncology (1:50pm - 5:00pm)
Session Chairs & Scientific Program Committee:
Le Ai Trinh, co-chair | Vance Lemmon, co-chair |
(University of Southern California) | (University of Miami) |
Phenotypic screening is increasingly dependent on modeling, computational approaches and 3D imaging to attack complex biological problems at both high-content and high-throughput. This has been especially empowering in oncology and neuroscience where the use of pluripotent stem cells, self-organized organoids and whole animal models are enabling screens for a range of cellular phenotypes from the electrophysiological profile of individual neurons to their degeneration. This session will highlight recent developments that expand our ability to understand the local environment in tumor progression and degeneration and regeneration of the nervous system.
2:00 - 2:30 | High content analysis of tumor-fibroblast crosstalk in colorectal cancer Invited Speaker, Shannon Mumenthaler, (University of Southern California) |
2:30 - 3:00 | Scalable Measurements of Intrinsic Excitability in Human iPS Cell- Derived Excitatory Neurons Using All-Optical Electrophysiology. Invited Speaker, Graham Dempsey, (Q-State Biosciences) |
3:00 - 3:10 | Spheroid Painting with DRAQ9™:Simple Identification and Measurement in 3D Cell Culture 10 Minute Spotlight, Roy Edward, (Biostatus) |
3:10 - 3:20 | FAST-HDR: A novel vector system for the rapid development of knock- in cell lines 10 Minute Spotlight, Oscar Perez-Leal, (Temple University) |
3:20 - 3:50 | Break for coffee - exhibit & poster viewing |
3:50 - 4:20 | Dynamic Arrays for Profiling Antitumor Activity of CAR T Cells Invited Speaker, Daniel Irimia, (Harvard Medical School, Massachusetts General Hospital ) |
4:20 - 4:40 | Using a novel colorectal cancer-on-chip model to investigate tumor microenvironment-mediated cancer progression Selected Abstract, Carly Strelez, (USC) |
4:40 - 5:00 | 3D Co-Cultures of Prostate Cancer Patient-Derived Xenografts, Stroma, and Endothelium in a Perfused Microplate Selected Abstract, Lindsey K Sablatura, (Rice University) |
5:00 - 5:30 | SBI2 Annual General Meeting (Amphitheater) |
5:30 - 6:30 |
SBI2 Sponsored Reception (Exhibit Hall) |
SBI2 Conference Scientific Program
8:00am - 3:00pm Exhibit & Poster viewing
8:50 - 9:00 Day 2 Opening Remarks. Myles Fennell, President SBI2
Session III: Therapeutic Drug Discovery for Complex Disease. (9:00am - 2:20pm)
Session Chairs & Scientific Program Committee:
George Lee, co-chair | Daniel Levner, co-chair |
(Bristol-Myers Squibb) | (Emulate) |
How HCS technologies and other imaging modalities support the understanding of complex diseases
Novel technologies such as 3D models and digital pathology are transforming drug development through the quality, complexity and human-relevance of the data they produce. In particular, recent advances in Organ-Chip and organoid technologies have provided new disease models that more closely recapitulate human disease, while advances in digital pathology and image analysis allow for the appreciation of spatial relationships within the tissue microenvironment. In this session we explore these technologies and address their potential to reveal mechanisms for therapeutic response.
Session IV: Machine Learning/Artificial Intelligence and/or Conventional outputs?
(2:00pm - 4:30pm)
Session Chairs & Scientific Program Committee:
Sam Cooper, co-chair | Neil O. Carragher, co-chair |
(Phenomic AI) | (MRC Institute of Genetics & Molecular Medicine) |
Machine learning has been a feature of drug discovery for almost four decades and delivered multiple successes, with early algorithms focused around in silico optimization of compounds. So what’s all the fuss about now? In contrast to the rules and simulation based approaches of past decades, new machine learning approaches such as deep-learning allow us to extract valuable insights from a wide variety of data types, including imaging, sequencing, and compound data, without having to explicitly engineer new features for each data type. In this session we will bring together a group of researchers working on state-of-the art techniques for microscopy image analysis, and explore how imaging data can be integrated with other data modalities to answer key questions in biological and pharmaceutical research.
2:15 - 2:45 | Deep learning for single cell biology Invited Speaker, David A. Van Valen, (California Institute of Technology) |
2:45- 3:15 | Machine learning: a new approach enabling drug discovery Invited Speaker, Eric Lubeck, (Insitro) |
3:15 - 3:45 | Break for coffee & exhibit viewing |
3:45 - 4:05 | Comparison of classical image analysis methods and deep-learning approaches for 3D single cell measurements within multi-cellular spheroids Selected Abstract, Ty Voss, (NCATS/NIH) |
4:05 - 4:25 | Nucleus segmentation across imaging experiments: The 2018 Data Science Bowl Selected Abstract, Juan Caicedo, (Broad Institute) |
4:25 - 4:45 | Awards Ceremony and Closing remarks Myles Fennell, President SBI2 |